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Colloidal Gold gene therapy

wallpapers News 2021-12-30
Colloidal Gold nanoparticles have shown potential as intracellular delivery vectors for siRNA oligonucleotides and have the greatest therapeutic effect.
Multifunctional siRNA gold nanoparticles with several biomolecules: polyethylene glycol, cell osmotic and cell adhesion peptides, and siRNA.Two different methods were used to bind siRNA to gold nanoparticles :(1) covalent method: siRNA was halogenated to bind gold-mercaptan to nanoparticles;(2) Ion pathway: negatively charged siRNA interacts with AuNP modified surfaces through ion interaction.
Gold nanoparticles have shown potential as intracellular delivery vectors for antisense oligonucleotides (single and double-stranded DNA) by protecting intracellular nucleases and selective targeting functionalization
Colloidal Gold photothermal spectrometric analysis agent
Colloidal Gold nanorods are being investigated as photothermal agents for in vivo applications. Gold nanorods are rod-shaped gold nanoparticles whose aspect ratio regulates the surface plasmon resonance (SPR) band from visible to near-infrared wavelengths. The total extinction of light on SPR consists of absorption and scattering. For nanorods with axial diameters less than 10 nm, absorption is dominant, while for nanorods with axial diameters greater than 35 nm, scattering is dominant. Therefore, in in vivo studies, small diameter gold nanorods have been used as photothermal transducers of near-infrared light due to their high absorption cross-section. Since near-infrared light easily penetrates human skin and tissues, these nanorods can be used as ablation components for cancer and other targets. When coated with polymers, gold nanorods have been observed to circulate in the body with a half-life of more than 6 hours and a residence time in the body of approximately 72 hours, with little or no absorption from any internal organs except the liver
Despite their undoubted success in preclinical studies as photothermal agents, gold nanorods have not yet been approved for clinical use due to their size exceeding the renal excretion threshold. In 2019, the first nanostructures of nir-absorbed plasma were reported, combined with :(I) the appropriate photothermal conversion for hyperthermia therapy, (ii) the possibility of multiple photothermal treatments, and (iii) renal excretion of blocks after treatment
Colloidal Gold radiotherapy dose enhancer
There has been a great deal of interest in using gold and other nanoparticles containing heavy atoms to boost the dose of tumors because gold nanoparticles are absorbed by tumors more than nearby healthy tissue, the dose is selectively enhanced. The biological effect of the treatment appears to be due to local deposition of radiation dose near nanoparticles by the same mechanism as heavy ion therapy.
 

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