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Silica "Coat" Makes Vaccine Resistant To High Temperature

wallpapers Industry 2020-07-14

As we all know, the vaccine needs to be kept in cold storage, and it is generally safe at 2 to 8 degrees Celsius. At other temperatures, the protein contained in the vaccine will disintegrate, causing the vaccine to lose its activity. Millions of children around the world have missed vaccine, but now this The situation is expected to become history. According to the physicist organization network reported on the 8th, British scientists skillfully put a layer of silica "coat" on the protein, even if heated to 100 degrees Celsius or stored at room temperature for up to three years, the vaccine structure is still intact.

In the latest study, the researchers mailed two copies of the tetanus vaccine from the University of Bath to Newcastle University (a distance of 300 miles between the two places and the delivery took one or two days) by ordinary mail. One vaccine "wears a silica coat"; the other is unprotected. The non-toxic material silica is the main component of sand.

It was found that the injection of "silicified" vaccine into mice successfully triggered an immune response, indicating that the vaccine was active. In contrast, the infusion of unprotected vaccine into mice did not trigger an immune response, indicating that the vaccine had been damaged during transportation.

Dr Issel Satabava, the head of the latest research and the Department of Chemistry at the University of Bath, said: "The research results are exciting. This new technology not only protects the protein structure of the vaccine, but also retains its function-the immunogen Sex."

Data Bava explained: "Our current focus is on tetanus vaccine, which is part of the DTP vaccine (diphtheria, tetanus and pertussis) vaccinated in children. Next, we will work to develop heat-stable diphtheria and Pertussis vaccine. Ultimately, we want to'siliconize' the entire DTP triple vaccine so that every child can get the DTP vaccine without relying on cold chain transportation."

Santa Bava said that the "silicified" vaccine could be used in humans within 5 to 15 years. She hopes that this "silicified" technology will eventually be used to store and transport all children's vaccines and other protein products such as antibodies and enzymes. "We The aim is to use heat-stable vaccines and reduce dependence on the cold chain to eradicate vaccine-preventable diseases in low-income countries."

It is reported that as a result of exposure to suboptimal temperatures, up to 50% vaccine is discarded before use. Data from the World Health Organization show that in 2018, 19.4 million babies were not vaccinated.


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Tag: Silica